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Article

An Interaction between the DNA Repair Factor XPA and Replication Protein A Appears Essential for Nucleotide Excision Repair

1 Oct 1995

Abstract excerpt

Replication protein A (RPA) is required for simian virus 40-directed DNA replication in vitro and for nucleotide excision repair (NER). Here we report that RPA and the human repair protein XPA specifically interact both in vitro and in vivo. Mapping of the RPA-interactive domains in XPA revealed that both of the largest subunits of RPA, RPA-70 and RPA-34, interact with XPA at distinct sites. A domain involved in...

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Identifiers

PMID: 7565690
DOI: 10.1128/mcb.15.10.5396

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