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Article

Promoter-hypermethylation associated defective expression of E-cadherin in primary non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Nov 2008

Wang Guiying, Hu Xiaohua, Lu Chenqi, Su Chengchang, Luo Shijing, Luo Z W

Abstract excerpt

Hypermethylation of CpG islands is well known as a major inactivation mechanism of tumor suppressor genes. E-cadherin (E-cad) as a tumor invasion suppressor has been reported in several invasive and metastatic carcinomas. However, its significance in carcinogenesis of primary non-small cell lung cancer (NSCLC) is not well documented. This study was designed to assess the significance with 95 pairs of carefully...

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Identifiers

PMID: 18468719
DOI: 10.1016/j.lungcan.2008.03.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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