Article
Expression of E-cadherin and beta-catenin in human non-small cell lung cancer and the clinical significance.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2000
Kase S, Sugio K, Yamazaki K, Okamoto T, Yano T, Sugimachi K
Abstract excerpt
E-cadherin, a calcium-dependent cell-cell adhesion molecule, plays a key role in the maintenance of tissue integrity. The function of this molecule is partly mediated by alpha-/beta-/gamma-catenin. Loss or dysfunction of E-cadherin is associated with an invasive phenotype. We analyzed the expression of E-cadherin and beta-catenin in human lung cancer to determine the relationship to clinicopathological factors...
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