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Article

E-Cadherin Gene Promoter Hypermethylation in Primary Human Gastric Carcinomas

5 Apr 2000

Abstract excerpt

BACKGROUND: E (epithelial)-cadherin, the cell adhesion molecule also considered a potential invasion/metastasis suppressor, is mutationally inactivated in nearly half of all undifferentiated-scattered (diffuse-type) gastric carcinomas. In addition, silencing of E-cadherin by CpG methylation within its promoter region has been reported in several gastric carcinoma cell lines. We investigated the methylation status...

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PMID: 10749913
DOI: 10.1093/jnci/92.7.569

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