Article
DNA methylation of microRNA-coding genes in non-small-cell lung cancer patients.
The Journal of pathology - 1 Aug 2018
Heller Gerwin, Altenberger Corinna, Steiner Irene, Topakian Thais, Ziegler Barbara, Tomasich Erwin, Lang György, End-Pfützenreuter Adelheid, Zehetmayer Sonja, Döme Balazs, Arns Britt-Madeleine, Klepetko Walter, Zielinski Christoph C, Zöchbauer-Müller Sabine
Abstract excerpt
Deregulated DNA methylation leading to transcriptional inactivation of certain genes occurs frequently in non-small-cell lung cancers (NSCLCs). As well as protein-coding genes, microRNA (miRNA)-coding genes may be targets for methylation in NSCLCs; however, the number of known methylated miRNA genes is still small. Thus, we investigated methylation of miRNA genes in primary tumour (TU) samples and corresponding...
Topics
- A549 Cells
- Biomarkers, Tumor
- Carcinoma, Non-Small-Cell Lung
- Cell Proliferation
- Chromatin Immunoprecipitation
- CpG Islands
- DNA Methylation
- Female
- Gene Expression Profiling