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Article

DNA methyltransferase inhibition reverses epigenetically embedded phenotypes in lung cancer preferentially affecting polycomb target genes.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2014

Hascher Antje, Haase Ann-Kristin, Hebestreit Katja, Rohde Christian, Klein Hans-Ulrich, Rius Maria, Jungen Dominik, Witten Anika, Stoll Monika, Schulze Isabell, Ogawa Seishi, Wiewrodt Rainer, Tickenbrock Lara, Berdel Wolfgang E, Dugas Martin, Thoennissen Nils H, Müller-Tidow Carsten

Abstract excerpt

PURPOSE: Cancer cell phenotypes are partially determined by epigenetic specifications, such as DNA methylation. Metastasis development is a late event in cancerogenesis and might be associated with epigenetic alterations. EXPERIMENTAL DESIGN: An in vivo selection approach was used to generate hig...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24334763
DOI: 10.1158/1078-0432.CCR-13-1483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-24334763-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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