Article
Targeted inhibition of genome-wide DNA methylation analysis in epigenetically modulated phenotypes in lung cancer.
Medical oncology (Northwood, London, England) - 1 Jun 2015
Dai Shou-Ping, Xie Chao, Ding Ning, Zhang Yi-Jun, Han Lei, Han Yun-Wei
Abstract excerpt
DNA methylation analysis, an epigenetic specification, has been explored for partial determination of cancer cell phenotypes. The development of metastasis in cancerogenesis has led its feasible association with the epigenetic modulations. We generated highly aggressive non-small cell lung cancer cell lines (HTB56 and A549) by using in vivo selection approach. These were, then, subjected to DNA methylation...
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