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Disruption of metF increased L-lysine production by Methylophilus methylotrophus from methanol.

Bioscience, biotechnology, and biochemistry - 1 May 2008

Ishikawa Kohei, Asahara Takayuki, Gunji Yoshiya, Yasueda Hisashi, Asano Kozo

Abstract excerpt

Methionine auxotrophic mutants of Methylophilus methylotrophus AS1 expressing a mutant form of dapA (dapA24) encoding a dihydrodipicolinate synthase desensitized from feedback inhibition by L-lysine, and mutated lysE (lysE24) encoding the L-lysine exporter from Corynebacterium glutamicum 2256, produced higher amounts of L-lysine from methanol as sole carbon source than did other amino acid auxotrophic mutants....

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PMID: 18460806
DOI: 10.1271/bbb.70818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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