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Article

Role of the Bacillus methanolicus citrate synthase II gene, citY, in regulating the secretion of glutamate in L-lysine-secreting mutants.

Applied and environmental microbiology - 1 Jul 2003

Brautaset Trygve, Williams Mark D, Dillingham Richard D, Kaufmann Christine, Bennaars Assumpta, Crabbe Edward, Flickinger Michael C

Abstract excerpt

The thermotolerant, restrictive methylotroph Bacillus methanolicus MGA3 (ATCC 53907) can secrete 55 g of glutamate per liter (maximum yield, 0.36 g/g) at 50 degrees C with methanol as a carbon source and a source of ammonia in fed-batch bioreactors. A homoserine dehydrogenase mutant, 13A52-8A66, secreting up to 35 g of L-lysine per liter in fed-batch fermentations had minimal 2-oxoglutarate dehydrogenase activity...

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Identifiers

PMID: 12839772
DOI: 10.1128/AEM.69.7.3986-3995.2003
PMCID: PMC165195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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