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Bacillus methanolicus pyruvate carboxylase and homoserine dehydrogenase I and II and their roles for L-lysine production from methanol at 50 degrees C.

Applied microbiology and biotechnology - 1 Jul 2010

Brautaset Trygve, Jakobsen Øyvind M, Degnes Kristin F, Netzer Roman, Naerdal Ingemar, Krog Anne, Dillingham Rick, Flickinger Michael C, Ellingsen Trond E

Abstract excerpt

We here present the pyc gene encoding pyruvate carboxylase (PC), and the hom-1 and hom-2 genes encoding two active homoserine dehydrogenase (HD) proteins, in methylotrophic Bacillus methanolicus MGA3. In general, both PC and HD are regarded as key targets for improving bacterial L-lysine production; PC plays a role in precursor oxaloacetate (OAA) supply while HD controls an important branch point in the L-lysine...

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PMID: 20372887
DOI: 10.1007/s00253-010-2559-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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