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Article

Analysis and manipulation of aspartate pathway genes for L-lysine overproduction from methanol by Bacillus methanolicus.

Applied and environmental microbiology - 1 Sept 2011

Nærdal Ingemar, Netzer Roman, Ellingsen Trond E, Brautaset Trygve

Abstract excerpt

We investigated the regulation and roles of six aspartate pathway genes in L-lysine overproduction in Bacillus methanolicus: dapG, encoding aspartokinase I (AKI); lysC, encoding AKII; yclM, encoding AKIII; asd, encoding aspartate semialdehyde dehydrogenase; dapA, encoding dihydrodipicolinate synthase; and lysA, encoding meso-diaminopimelate decarboxylase. Analysis of the wild-type strain revealed that in vivo...

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Identifiers

PMID: 21724876
DOI: 10.1128/AEM.05093-11
PMCID: PMC3165430

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