Article
Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2011
Sandbulte Matthew R, Westgeest Kim B, Gao Jin, Xu Xiyan, Klimov Alexander I, Russell Colin A, Burke David F, Smith Derek J, Fouchier Ron A M, Eichelberger Maryna C
Abstract excerpt
Seasonal epidemics caused by influenza virus are driven by antigenic changes (drift) in viral surface glycoproteins that allow evasion from preexisting humoral immunity. Antigenic drift is a feature of not only the hemagglutinin (HA), but also of neuraminidase (NA). We have evaluated the antigenic evolution of each protein in H1N1 and H3N2 viruses used in vaccine formulations during the last 15 y by analysis of...
Topics
- Animals
- Antigens
- Evolution, Molecular
- Ferrets
- Hemagglutinin Glycoproteins, Influenza Virus
- Humans
- Influenza A Virus, H1N1 Subtype
- Influenza A Virus, H3N2 Subtype
- Influenza Vaccines
- Influenza, Human
- Models, Molecular
- Molecular Conformation