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Article

Mapping the antigenic and genetic evolution of influenza virus.

Science (New York, N.Y.) - 16 Jul 2004

Smith Derek J, Lapedes Alan S, de Jong Jan C, Bestebroer Theo M, Rimmelzwaan Guus F, Osterhaus Albert D M E, Fouchier Ron A M

Abstract excerpt

The antigenic evolution of influenza A (H3N2) virus was quantified and visualized from its introduction into humans in 1968 to 2003. Although there was remarkable correspondence between antigenic and genetic evolution, significant differences were observed: Antigenic evolution was more punctuated...

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Source

Identifiers

PMID: 15218094
DOI: 10.1126/science.1097211

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15218094-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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