Article
Glycosylation focuses sequence variation in the influenza A virus H1 hemagglutinin globular domain.
PLoS pathogens - 24 Nov 2010
Das Suman R, Puigbò Pere, Hensley Scott E, Hurt Darrell E, Bennink Jack R, Yewdell Jonathan W
Abstract excerpt
Antigenic drift in the influenza A virus hemagglutinin (HA) is responsible for seasonal reformulation of influenza vaccines. Here, we address an important and largely overlooked issue in antigenic drift: how does the number and location of glycosylation sites affect HA evolution in man? We analyzed the glycosylation status of all full-length H1 subtype HA sequences available in the NCBI influenza database. We...
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