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Article

HIV coreceptor tropism determination and mutational pattern identification.

Scientific reports - 17 Feb 2016

Shen Hui-Shuang, Yin Jason, Leng Fei, Teng Rui-Fang, Xu Chao, Xia Xia-Yu, Pan Xian-Ming

Abstract excerpt

In the early stages of infection, Human Immunodeficiency Virus Type 1 (HIV-1) generally selects CCR5 as the primary coreceptor for entering the host cell. As infection progresses, the virus evolves and may exhibit a coreceptor-switch to CXCR4. Accurate determination coreceptor usage and identification key mutational patterns associated tropism switch are essential for selection of appropriate therapies and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26883082
DOI: 10.1038/srep21280
PMCID: PMC4756667

Genes

MCC
CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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