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Article

The C/EBPδ tumor suppressor is silenced by hypermethylation in acute myeloid leukemia

18 Jan 2007

Abstract excerpt

Aberrant DNA methylation is the most frequent molecular alteration in acute myeloid leukemia (AML). To identify methylation-silenced genes in AML, we performed microarray analyses in U937 cells exposed to the demethylating agent 5-aza-deoxy-cytidine. Overall, 274 transcripts were significantly induced. Interestingly, C/EBPdelta expression was significantly induced (more than 10-fold) by demethylation whereas...

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PMID: 17234736
DOI: 10.1182/blood-2006-08-040147

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