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Article

Revealing the moonlighting role of NADP in the structure of a flavin-containing monooxygenase.

Proceedings of the National Academy of Sciences of the United States of America - 6 May 2008

Alfieri Andrea, Malito Enrico, Orru Roberto, Fraaije Marco W, Mattevi Andrea

Abstract excerpt

Flavin-containing monooxygenases (FMOs) are, after cytochromes P450, the most important monooxygenase system in humans and are involved in xenobiotics metabolism and variability in drug response. The x-ray structure of a soluble prokaryotic FMO from Methylophaga sp. strain SK1 has been solved at 2.6-A resolution and is now the protein of known structure with the highest sequence similarity to human FMOs. The...

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Source

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Identifiers

PMID: 18443301
DOI: 10.1073/pnas.0800859105
PMCID: PMC2373336

Genes

FMO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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