Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of genetic variants of the human flavin-containing monooxygenase 3 on N- and S-oxygenation activities.

Drug metabolism and disposition: the biological fate of chemicals - 1 Mar 2007

Shimizu Makiko, Yano Hiroshi, Nagashima Satomi, Murayama Norie, Zhang Jun, Cashman John R, Yamazaki Hiroshi

Abstract excerpt

The decreased capacity of the flavin-containing monooxygenase 3 (FMO3) to oxygenate xenobiotics including trimethylamine is believed to contribute to metabolic disorders. The aim of this study was to functionally characterize FMO3 variants recently found in a Japanese population and compare them with selective functional activity of other FMO3 variants. Recombinant Glu158Lys and Glu158Lys-Glu308Gly FMO3 expressed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Escherichia coli
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methylamines

Share to Nitrogen

Share to Oxygen

Share to Oxygenases

Share to Sulfides

Share to Sulfur

Source

Identifiers

PMID: 17142560
DOI: 10.1124/dmd.106.013094

Genes

FMO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of genetic variants of the human flavin-containing monooxygenase 3 on N- and S-oxygenation activities.PMID 17142560Read ↗

Survey of variants of human flavin-containing monooxygenase 3 (FMO3) and their drug oxidation activities.Semantic proximity Read ↗

Genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects identified by phenotyping for trimethylaminuria and found in a database of genome resources.Semantic proximity Read ↗

Variants in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population.Semantic proximity Read ↗

Novel variants of the human flavin-containing monooxygenase 3 (FMO3) gene associated with trimethylaminuria.Semantic proximity Read ↗

Flavin-containing monooxygenase 3 (FMO3): genetic variants and their consequences for drug metabolism and diseaseSemantic proximity Read ↗

Flavin-containing monooxygenase 3 and human disease.Semantic proximity Read ↗

Mutation, polymorphism and perspectives for the future of human flavin-containing monooxygenase 3.Semantic proximity Read ↗

Human flavin-containing monooxygenase (form 3): polymorphisms and variations in chemical metabolism.Semantic proximity Read ↗

Genetic polymorphism of the flavin-containing monooxygenase 3 (FMO3) associated with trimethylaminuria (fish odor syndrome): observations from Japanese patients.Semantic proximity Read ↗

Trimethylamine N-oxygenation in cynomolgus macaques genotyped for flavin-containing monooxygenase 3 (FMO3).Semantic proximity Read ↗

Relationships between flavin-containing mono-oxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population.Semantic proximity Read ↗

Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.