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Article

Inactivation mechanism of N61S mutant of human FMO3 towards trimethylamine.

Scientific reports - 7 Nov 2017

Gao Chongliang, Catucci Gianluca, Castrignanò Silvia, Gilardi Gianfranco, Sadeghi Sheila J

Abstract excerpt

Human flavin-containing monooxygenase 3 (hFMO3) catalyses the oxygenation of a wide variety of compounds including drugs as well as dietary compounds. It is the major hepatic enzyme involved in the production of the N-oxide of trimethylamine (TMAO) and clinical studies have uncovered a striking correlation between plasma TMAO concentration and cardiovascular disease. Certain mutations within the hFMO3 gene cause...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29116146
DOI: 10.1038/s41598-017-15224-9
PMCID: PMC5676948

Genes

FMO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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