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Article

Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs.

Nature structural & molecular biology - 1 Jan 2020

Nicoll Callum R, Bailleul Gautier, Fiorentini Filippo, Mascotti María Laura, Fraaije Marco W, Mattevi Andrea

Abstract excerpt

Flavin-containing monooxygenases (FMOs) are ubiquitous in all domains of life and metabolize a myriad of xenobiotics, including toxins, pesticides and drugs. However, despite their pharmacological importance, structural information remains bereft. To further our understanding behind their biochemistry and diversity, we used ancestral-sequence reconstruction, kinetic and crystallographic techniques to scrutinize...

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PMID: 31873300
DOI: 10.1038/s41594-019-0347-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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