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Article

Oxidation of the FAD cofactor to the 8-formyl-derivative in human electron-transferring flavoprotein.

The Journal of biological chemistry - 23 Feb 2018

Augustin Peter, Toplak Marina, Fuchs Katharina, Gerstmann Eva Christine, Prassl Ruth, Winkler Andreas, Macheroux Peter

Abstract excerpt

The heterodimeric human (h) electron-transferring flavoprotein (ETF) transfers electrons from at least 13 different flavin dehydrogenases to the mitochondrial respiratory chain through a non-covalently bound FAD cofactor. Here, we describe the discovery of an irreversible and pH-dependent oxidation of the 8α-methyl group to 8-formyl-FAD (8f-FAD), which represents a unique chemical modification of a flavin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29301933
DOI: 10.1074/jbc.RA117.000846
PMCID: PMC5827430

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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