Article
Differences in the contribution of the CTLA4 gene to susceptibility to fulminant and type 1A diabetes in Japanese patients.
Diabetes care - 1 Aug 2008
Kawasaki Eiji, Imagawa Akihisa, Makino Hideichi, Uga Miho, Abiru Norio, Hanafusa Toshiaki, Uchigata Yasuko, Eguchi Katsumi
Abstract excerpt
OBJECTIVE: To examine the contribution of the CTLA4 gene in the susceptibility to fulminant type 1 diabetes and compare it with classic type 1A diabetes. RESEARCH DESIGN AND METHODS: We genotyped the +49G>A and CT60G>A variants of the CTLA4 gene in fulminant type 1 diabetic patients (n = 55), classic type 1A diabetic patients (n = 91), and healthy control subjects (n = 369). We also assessed serum levels of the...
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