Article
Association between CTLA-4 +49 A/G polymorphism and type 1B diabetes in Japanese population.
Endocrine - 1 Nov 2004
Liang Hua, Yagi Kunimasa, Asano Akimichi, Kobayashi Junji, Mabuchi Hiroshi
Abstract excerpt
+49 A/G polymorphism of CTLA-4 gene has been suggested to be associated with type 1 diabetes in some populations. However, a functional significance of the +49 A/G polymorphism is unknown, because it is believed the polymorphism does not affect the function of the CTLA-4 molecule. In this study, we examined the +49 A/G polymorphism of the CTLA-4 gene in 30 Japanese type 1 diabetic patients (14 type 1B and 16 type...
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