Article
Allelic variant in CTLA4 is associated with thyroid failure and faster β-cell exhaustion in latent autoimmune diabetes in adults.
Journal of diabetes - 1 Jan 2015
Delitala Alessandro P, Fanciulli Giuseppe, Zoledziewska Magdalena, Pitzalis Maristella, Pusceddu Pierpaolo, Frongia Paola, Puddu Loreta, Errigo Alessandra, Maioli Margherita, Delitala Giuseppe, Pes Giovanni M
Abstract excerpt
BACKGROUND: The aim of the study was to investigate the role of the cytotoxic T-lymphocyte-associated protein 4 (CTLA4) G6230A variant on the susceptibility of latent autoimmune diabetes in adults (LADA) as a whole and in the subset of patients who share autoimmune thyroid disease (AITD). METHODS: The study included 202 LADA, 1373 patients with early onset type 1 diabetes (T1D), 130 patients with late-onset T1D,...
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