Article
Association between CTLA-4 polymorphisms and the susceptibility to systemic lupus erythematosus and Graves' disease in Thai population.
Asian Pacific journal of allergy and immunology - 1 Sept 2011
Kimkong Ingorn, Nakkuntod Jeerawat, Sae-Ngow Siriwalee, Snabboon Thiti, Avihingsanon Yingyos, Hirankarn Nattiya
Abstract excerpt
BACKGROUND: Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a cell surface molecule involved in the regulation of T cells. Single nucleotide polymorphisms (SNPs) of CTLA-4 gene are known to be associated with susceptibility to several autoimmune diseases, including systemic lupus erythematosus (SLE) and Graves' disease (GD). OBJECTIVE: The aim of this study was to determine whether the common SNPs +49A/G on exon1...
Topics
- 3' Untranslated Regions
- Adult
- Alleles
- Asian People
- CTLA-4 Antigen
- Exons
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Graves Disease