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Article

CTLA-4 +49 A/G polymorphism is associated with predisposition to type 1 diabetes in Iranians.

Diabetes research and clinical practice - 1 May 2005

Mojtahedi Zahra, Omrani Gholamhossein R, Doroudchi Mehrnoosh, Ghaderi Abbas

Abstract excerpt

CTLA-4 is a homeostatic regulator of T cell activation and is believed to play a critical role in peripheral tolerance. The contribution of CTLA-4 gene variants to type 1 diabetes has been analyzed in several ethnic groups. In this study, the association of CTLA-4 +49 A/G polymorphism with type 1 diabetes was investigated in Iranian patients. One hundred and nine patients and 331 healthy subjects formed the...

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Identifiers

PMID: 15860238
DOI: 10.1016/j.diabres.2004.08.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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