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Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks

15 Apr 2008

Abstract excerpt

DNA nonhomologous end-joining (NHEJ) and homologous recombination are two distinct pathways of DNA double-strand break repair in mammalian cells. Biochemical and genetic studies showed that DNA ends can also be joined via microhomology-mediated end joining (MHEJ), especially when proteins responsible for NHEJ, such as Ku, are reduced or absent. While it has been known that Ku-dependent NHEJ requires DNA ligase...

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PMID: 18440984
DOI: 10.1093/nar/gkn184

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Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaksPMID 18440984Read ↗

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