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Article

DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes.

Molecular cell - 1 Oct 1998

Grawunder U, Zimmer D, Fugmann S, Schwarz K, Lieber M R

Abstract excerpt

Nonhomologous DNA end joining (NHEJ) is the major pathway for repairing double-strand DNA breaks. V(D)J recombination is a double-strand DNA breakage and rejoining process that relies on NHEJ for the joining steps. Here we show that the targeted disruption of both DNA ligase IV alleles in a human pre-B cell line renders the cells sensitive to ionizing radiation and ablates V(D)J recombination. This phenotype can...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9809069
DOI: 10.1016/s1097-2765(00)80147-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes.PMID 9809069Read ↗

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Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice.Semantic proximity Read ↗

Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaksSemantic proximity Read ↗

Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells.Semantic proximity Read ↗

Impact of DNA ligase IV on the fidelity of end joining in human cells.Semantic proximity Read ↗

NHEJ deficiency and disease.Semantic proximity Read ↗

Altered DNA ligase activity in human diseaseSemantic proximity Read ↗

The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants.Semantic proximity Read ↗

Identification of Genes Involved in Repair of DNA Double-Strand Breaks in Mammalian CellsSemantic proximity Read ↗

Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4Semantic proximity Read ↗

DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency.Semantic proximity Read ↗

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