DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes.

doi:10.1016/s1097-2765(00)80147-1

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Article

DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes.

Molecular cell - 1 Oct 1998

Grawunder U, Zimmer D, Fugmann S, Schwarz K, Lieber M R

Abstract excerpt

Nonhomologous DNA end joining (NHEJ) is the major pathway for repairing double-strand DNA breaks. V(D)J recombination is a double-strand DNA breakage and rejoining process that relies on NHEJ for the joining steps. Here we show that the targeted disruption of both DNA ligase IV alleles in a human...

Topics

Alleles
B-Lymphocytes
Cells, Cultured
DNA Ligase ATP
DNA Ligases
DNA Nucleotidyltransferases
DNA Repair
DNA, Complementary
Genetic Complementation Test
Humans
Mutagenesis
Phenotype
VDJ Recombinases

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