Article
9p21 locus analysis in high-risk gastrointestinal stromal tumors characterized for c-kit and platelet-derived growth factor receptor alpha gene alterations.
Cancer - 1 Jul 2005
Perrone Federica, Tamborini Elena, Dagrada Gian Paolo, Colombo Federica, Bonadiman Lorena, Albertini Veronica, Lagonigro Maria Stefania, Gabanti Elisa, Caramuta Stefano, Greco Angela, Torre Gabriella Della, Gronchi Alessandro, Pierotti Marco Alessandro, Pilotti Silvana
Abstract excerpt
BACKGROUND: Gastrointestinal stromal tumors (GISTs) are noncomplex sarcomas that often are due to c-kit-activating and platelet-derived growth factor receptor alpha gene (PDGFRalpha)-activating mutations and perturbations of their related signaling pathways. Molecular and cytogenetic findings have indicated correlations between tumor progression and high-risk GISTs with c-kit mutations, the overexpression of...
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