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Article

p16 overexpression and 9p21 deletion are linked to unfavorable tumor phenotype in breast cancer.

Oncotarget - 6 Dec 2016

Lebok Patrick, Roming Magdalena, Kluth Martina, Koop Christina, Özden Cansu, Taskin Berivan, Hussein Khakan, Lebeau Annette, Witzel Isabell, Wölber Linn, Geist Stefan, Paluchowski Peter, Wilke Christian, Heilenkötter Uwe, Müller Volkmar, Schmalfeldt Barbara, Simon Ronald, Sauter Guido, Terracciano Luigi, Krech Rainer Horst, von der Assen Albert, Burandt Eike

Abstract excerpt

Overexpression of the p16 tumor suppressor, but also deletion of its gene locus 9p21, is linked to unfavorable tumor phenotype and poor prognosis in breast cancer. To better understand these contradictory observations, and to clarify the prognostic impact of p16 expression and 9p21 deletion, a tissue microarray (TMA) with 2,197 breast cancers was analyzed by fluorescence in-situ hybridization and...

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Identifiers

PMID: 27835607
DOI: 10.18632/oncotarget.13227
PMCID: PMC5348395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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