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Article

Cell cycle regulators in testicular cancer: Loss of p18INK4C marks progression from carcinomain situ to invasive germ cell tumours

1 Feb 2000

Abstract excerpt

Cell cycle regulators govern cellular proliferation, modulate differentiation and, when defective, contribute to oncogenesis. Here, we examined expression of cyclins A, B1 and E, and cyclin-dependent kinase (CDK) inhibitors p18INK4C (p18), p21WAF1/Cip1 (p21) and p27KiP1 (p27), in normal human adult testis (n = 5), and 53 testicular tumours, including 23 carcinomas in situ (CIS) and 30 germ cell tumours (GCTs)....

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PMID: 10652429
DOI: 10.1002/(sici)1097-0215(20000201)85:3<370::aid-ijc13>3.0.co;2-a

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