Article
Extracellular signal-regulated kinases control expression of G protein-coupled receptor kinase 2 (GRK2).
FEBS letters - 8 May 2002
Theilade Juliane, Lerche Hansen Jakob, Haunsø Stig, Sheikh Søren P
Abstract excerpt
G protein-coupled receptor kinase 2 (GRK2) phosphorylates G protein-coupled receptors resulting in uncoupling from G proteins. Receptors modulate GRK2 expression, however the mechanistic basis for this effect is largely unknown. Here we report a novel mechanism by which receptors use the extracel...
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