Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases.

Proceedings of the National Academy of Sciences of the United States of America - 11 May 1999

Dicker F, Quitterer U, Winstel R, Honold K, Lohse M J

Abstract excerpt

Homologous desensitization of G protein-coupled receptors is thought to occur in several steps: binding of G protein-coupled receptor kinases (GRKs) to receptors, receptor phosphorylation, kinase dissociation, and finally binding of beta-arrestins to phosphorylated receptors. It generally is assu...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COS Cells
Share to Eye Proteins
Share to GTP-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP Phosphohydrolases

Share to Inositol Phosphates

Share to Parathyroid Hormone

Share to Phosphoproteins

Share to Phosphorylation

Source

Open in PubMed Open full text

Identifiers

PMID: 10318908
DOI: 10.1073/pnas.96.10.5476
PMCID: PMC21884

Genes

PTH
GRK2
GRK3
GRK5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10318908-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases.PMID 10318908Read ↗

Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases (GRKs).Semantic proximity Read ↗

Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization.Semantic proximity Read ↗

Eliminating phosphorylation sites of the parathyroid hormone receptor type 1 differentially affects stimulation of phospholipase C and receptor internalization.Semantic proximity Read ↗

GRK2-dependent desensitization downstream of G proteins.Semantic proximity Read ↗

Reduced G-protein-coupled-receptor kinase 2 activity results in impairment of osteoblast function.Semantic proximity Read ↗

Protein kinases that phosphorylate activated G protein-coupled receptors.Semantic proximity Read ↗

Agonist- and protein kinase C-induced phosphorylation have similar functional consequences for gastrin-releasing peptide receptor signaling via Gq.Semantic proximity Read ↗

G protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor.Semantic proximity Read ↗

Impact of impaired receptor internalization on calcium homeostasis in knock-in mice expressing a phosphorylation-deficient parathyroid hormone (PTH)/PTH-related peptide receptor.Semantic proximity Read ↗

Desensitization and internalization of the m2 muscarinic acetylcholine receptor are directed by independent mechanisms.Semantic proximity Read ↗

Agonist-induced endocytosis and receptor phosphorylation mediate resensitization of dopamine D(2) receptors.Semantic proximity Read ↗

Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.