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Potential Regulatory Roles of GRK2 in Endothelial Cell Activity and Pathological Angiogenesis

15 Jul 2021

Abstract excerpt

G protein-coupled receptor (GPCR) kinase 2 (GRK2) is an integrative node in many signaling network cascades. Emerging evidence indicates that GRK2 can interact with a large number of GPCRs and non-GPCR substrates in both kinase-dependent and -independent modes. Some of these pathways are associated with endothelial cell (EC) activity. The active state of ECs is a pivotal factor in angiogenesis. The occurrence and...

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PMID: 34335610
DOI: 10.3389/fimmu.2021.698424

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