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Article

Thyroid hormone action is required for normal cone opsin expression during mouse retinal development.

Investigative ophthalmology & visual science - 1 May 2008

Pessôa Cristiano N, Santiago Leticia A, Santiago Diana A, Machado Danielle S, Rocha Fernando A F, Ventura Dora F, Hokoç Jan Nora, Pazos-Moura Carmen C, Wondisford Fredric E, Gardino Patricia F, Ortiga-Carvalho Tania M

Abstract excerpt

PURPOSE: The expression of S- and M-opsins in the murine retina is altered in different transgenic mouse models with mutations in the thyroid hormone receptor (TR)-beta gene, demonstrating an important role of thyroid hormone (TH) in retinal development. METHODS: The spatial expression of S- and M-opsin was compared in congenital hypothyroidism and in two different TR mutant mouse models. One mouse model contains...

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Identifiers

PMID: 18436838
DOI: 10.1167/iovs.07-0908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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