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Thyroid hormone receptors mediate two distinct mechanisms of long-wavelength vision

15 Jun 2020

Abstract excerpt

Thyroid hormone (TH) signaling plays an important role in the regulation of long-wavelength vision in vertebrates. In the retina, thyroid hormone receptor β ( thrb ) is required for expression of long-wavelength-sensitive opsin ( lws ) in red cone photoreceptors, while in retinal pigment epithelium (RPE), TH regulates expression of a cytochrome P450 enzyme, cyp27c1 , that converts vitamin A 1 into vitamin A 2 to...

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PMID: 32541022
DOI: 10.1073/pnas.1920086117

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