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Article

Complete activation of thyroid hormone receptor β by T3 is essential for normal cochlear function and morphology in mice.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2011

Richter Claus-Peter, Münscher Adrian, Machado Danielle Santana, Wondisford Fredric E, Ortiga-Carvalho Tania M

Abstract excerpt

BACKGROUND/AIMS: Thyroid hormones (THs) regulate many developmental processes, including the developmental onset of cochlear differentiation and function. TH action is mediated mostly by triiodothyronine (T3) bound to thyroid hormone nuclear receptors (TRs). At positive regulated genes and in the absence of THs, nuclear co-repressors are bound to TRs and decrease basal transcription rate. Ligand (T(3)) binding...

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Identifiers

PMID: 22178950
DOI: 10.1159/000335812
PMCID: PMC3709180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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