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Article

Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo.

The Journal of clinical investigation - 1 Aug 2003

Shibusawa Nobuyuki, Hashimoto Koshi, Nikrodhanond Amisra A, Liberman M Charles, Applebury Meredithe L, Liao Xiao Hui, Robbins Janet T, Refetoff Samuel, Cohen Ronald N, Wondisford Fredric E

Abstract excerpt

Thyroid hormone action is mediated by thyroid hormone receptors (TRs), which are members of the nuclear hormone receptor superfamily. DNA-binding is presumed to be essential for all nuclear actions of thyroid hormone. To test this hypothesis in vivo, the DNA-binding domain of TR-beta was mutated within its P-box (GS mutant) using gene targeting techniques. This mutation in vitro completely abolishes TR-beta...

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Identifiers

PMID: 12925699
DOI: 10.1172/JCI18377
PMCID: PMC171393

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Source receipt: pubmed, retrieved 7 Sept 2026.

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