Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thyroid hormone receptors: lessons from knockout and knock-in mutant mice.

Trends in endocrinology and metabolism: TEM - 1 Mar 2003

Flamant Frédéric, Samarut Jacques

Abstract excerpt

The genes encoding thyroid hormone receptor alpha and beta (TRalpha and TRbeta) encode four thyroid hormone receptors and four variant isoforms with antagonistic properties. Because of this complexity, numerous models of TR mutation have been developed to understand the functions of specific receptors. In total, 13 mutant strains are now available. Phenotype analysis has shown that the two genes serve distinct...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Phenotype
Share to Mice
Share to Mice, Knockout

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Receptors, Thyroid Hormone

Share to Signal Transduction

Share to Thyroid Hormone Receptors alpha

Share to Thyroid Hormone Receptors beta

Source

Identifiers

PMID: 12591179
DOI: 10.1016/s1043-2760(02)00043-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thyroid hormone receptors: lessons from knockout and knock-in mutant mice.PMID 12591179Read ↗

Functions of thyroid hormone receptors in mice.Semantic proximity Read ↗

Isoform-dependent actions of thyroid hormone nuclear receptors: lessons from knockin mutant mice.Semantic proximity Read ↗

Use of a new model of transgenic mice to clarify the respective functions of thyroid hormone receptors in vivo.Semantic proximity Read ↗

Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation.Semantic proximity Read ↗

Ablation of TRalpha2 and a concomitant overexpression of alpha1 yields a mixed hypo- and hyperthyroid phenotype in mice.Semantic proximity Read ↗

Insight into the physiological actions of thyroid hormone receptors from genetically modified mice.Semantic proximity Read ↗

A point mutation in the activation function 2 domain of thyroid hormone receptor alpha1 expressed after CRE-mediated recombination partially recapitulates hypothyroidism.Semantic proximity Read ↗

A targeted dominant negative mutation of the thyroid hormone alpha 1 receptor causes increased mortality, infertility, and dwarfism in mice.Semantic proximity Read ↗

Severe psychomotor and metabolic damages caused by a mutant thyroid hormone receptor alpha 1 in mice: can patients with a similar mutation be found and treated?Semantic proximity Read ↗

Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development.Semantic proximity Read ↗

Marked potentiation of the dominant negative action of a mutant thyroid hormone receptor beta in mice by the ablation of one wild-type beta allele.Semantic proximity Read ↗

Genetic analysis reveals different functions for the products of the thyroid hormone receptor alpha locus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.