Thyroid hormone receptors: lessons from knockout and knock-in mutant mice.

doi:10.1016/s1043-2760(02)00043-7

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Article

Thyroid hormone receptors: lessons from knockout and knock-in mutant mice.

Trends in endocrinology and metabolism: TEM - 1 Mar 2003

Flamant Frédéric, Samarut Jacques

Abstract excerpt

The genes encoding thyroid hormone receptor alpha and beta (TRalpha and TRbeta) encode four thyroid hormone receptors and four variant isoforms with antagonistic properties. Because of this complexity, numerous models of TR mutation have been developed to understand the functions of specific receptors. In total, 13 mutant strains are now available. Phenotype analysis has shown that the two genes serve distinct...

Topics

Animals
Mice
Mice, Knockout
Mice, Transgenic
Phenotype
Receptors, Thyroid Hormone
Signal Transduction
Thyroid Hormone Receptors alpha
Thyroid Hormone Receptors beta

Source

Open in PubMed

Identifiers

PMID: 12591179
DOI: 10.1016/s1043-2760(02)00043-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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