Article
Genetic analysis of thyroid hormone receptors in development and disease.
Recent progress in hormone research - 1 Jan 1996
Forrest D, Golarai G, Connor J, Curran T
Abstract excerpt
Thyroid hormone (T3) fulfills diverse functions in vertebrate development and physiology. These functions are thought to be mediated by two genes encoding the related T3 receptors. TR alpha and TR beta. The use of homologous recombination in embryonic stem cells to generate defined, single-gene mutations provides a powerful means to investigate the individual functions of TR alpha and TR beta in mice. We have...
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