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Article

Use of a new model of transgenic mice to clarify the respective functions of thyroid hormone receptors in vivo.

Heart failure reviews - 1 Mar 2010

Flamant Frédéric, Quignodon Laure

Abstract excerpt

3,5,3'-Triido-L: -thyronine (T3) exerts pleiotropic actions on development and homeostasis mostly via its nuclear receptors, TRalpha1, TRbeta1, and TRbeta2, encoded by the THRA and THRB genes. Muouse genetics data outline the contrasting functions of THRA and THRB, and suggest that these are dictated by both the respective abundance of the receptor isoforms in a given cell type and the differences in the...

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Source

Identifiers

PMID: 19137427
DOI: 10.1007/s10741-008-9121-y

Genes

THRA
THRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Use of a new model of transgenic mice to clarify the respective functions of thyroid hormone receptors in vivo.PMID 19137427Read ↗

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Ablation of TRalpha2 and a concomitant overexpression of alpha1 yields a mixed hypo- and hyperthyroid phenotype in mice.Semantic proximity Read ↗

Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development.Semantic proximity Read ↗

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