Article
A point mutation in the activation function 2 domain of thyroid hormone receptor alpha1 expressed after CRE-mediated recombination partially recapitulates hypothyroidism.
Molecular endocrinology (Baltimore, Md.) - 1 Oct 2007
Quignodon Laure, Vincent Séverine, Winter Harald, Samarut Jacques, Flamant Frédéric
Abstract excerpt
Thyroid hormones act directly on transcription by binding to TRalpha1, TRbeta1, and TRbeta2 nuclear receptors, regulating many aspects of postnatal development and homeostasis. To analyze precisely the implication of the widely expressed TRalpha1 isoform in this pleiotropic action, we have generated transgenic mice with a point mutation in the TRalpha1 coding sequence, which is expressed only after...
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