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Article

Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis.

Annals of the rheumatic diseases - 1 Apr 2009

Dieguez-Gonzalez R, Akar S, Calaza M, Perez-Pampin E, Costas J, Torres M, Vicario J L, Velloso M L, Navarro F, Narvaez J, Joven B, Herrero-Beaumont G, Gonzalez-Alvaro I, Fernandez-Gutierrez B, de la Serna A R, Carreño L, Lopez-Longo J, Caliz R, Collado-Escobar M D, Blanco F J, Fernandez-Lopez C, Balsa A, Pascual-Salcedo D, Gomez-Reino J J, Gonzalez A

Abstract excerpt

OBJECTIVE: To examine genetic association between rheumatoid arthritis (RA) and known polymorphisms in core genes of the nuclear factor (NF)kappaB pathway, the major intracellular pathway in RA pathogenesis. METHODS: Discovery and replication sample sets of Spanish patients with RA and controls were studied. A total of 181 single nucleotide polymorphisms (SNPs) uniformly spaced along the genomic sequences of 17...

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Source

Identifiers

PMID: 18434448
DOI: 10.1136/ard.2007.087304

Genes

IKBKE
IKBKB
REL
NFKB1
NFKB2
NFKBIA
NFKBIB
NFKBIE
RELA
RELB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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