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Article

Functional variants in NFKBIE and RTKN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese.

PLoS genetics - 1 Sept 2012

Myouzen Keiko, Kochi Yuta, Okada Yukinori, Terao Chikashi, Suzuki Akari, Ikari Katsunori, Tsunoda Tatsuhiko, Takahashi Atsushi, Kubo Michiaki, Taniguchi Atsuo, Matsuda Fumihiko, Ohmura Koichiro, Momohara Shigeki, Mimori Tsuneyo, Yamanaka Hisashi, Kamatani Naoyuki, Yamada Ryo, Nakamura Yusuke, Yamamoto Kazuhiko

Abstract excerpt

Rheumatoid arthritis is an autoimmune disease with a complex etiology, leading to inflammation of synovial tissue and joint destruction. Through a genome-wide association study (GWAS) and two replication studies in the Japanese population (7,907 cases and 35,362 controls), we identified two gene...

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Source

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Identifiers

PMID: 23028356
DOI: 10.1371/journal.pgen.1002949
PMCID: PMC3441678

Genes

NFKBIE
RTKN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23028356-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Functional variants in NFKBIE and RTKN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese.PMID 23028356Read ↗

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