Article
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
Nature genetics - 1 Jul 2009
Gregersen Peter K, Amos Chistopher I, Lee Annette T, Lu Yue, Remmers Elaine F, Kastner Daniel L, Seldin Michael F, Criswell Lindsey A, Plenge Robert M, Holers V Michael, Mikuls Ted R, Sokka Tuulikki, Moreland Larry W, Bridges S Louis, Xie Gang, Begovich Ann B, Siminovitch Katherine A
Abstract excerpt
We conducted a genome-wide association study of rheumatoid arthritis in 2,418 cases and 4,504 controls from North America and identified an association at the REL locus, encoding c-Rel, on chromosome 2p13 (rs13031237, P = 6.01 x 10(-10)). Replication in independent case-control datasets comprising 2,604 cases and 2,882 controls confirmed this association, yielding an allelic OR = 1.25 (P = 3.08 x 10(-14)) for...
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