Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice.

Journal of virology - 1 Jul 2008

Turelli Priscilla, Liagre-Quazzola Alexandra, Mangeat Bastien, Verp Sonia, Jost Stephanie, Trono Didier

Abstract excerpt

Interferon (IFN) has been part of the standard treatment of chronic hepatitis B infection for more than 2 decades, yet the mechanism of action of this antiviral remains poorly understood. It was recently observed that members of the human APOBEC family of cytidine deaminases endowed with anti-hepatitis B virus (HBV) activity are upregulated by type I and II IFNs. However, we demonstrated that, in tissue culture,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytidine Deaminase
Share to Hepatitis B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B virus

Share to Immunoprecipitation

Share to Interferons

Share to Mice, Transgenic

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 18434399
DOI: 10.1128/JVI.00216-08
PMCID: PMC2447049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice.PMID 18434399Read ↗

Interferon‐inducible expression of APOBEC3 editing enzymes in human hepatocytes and inhibition of hepatitis B virus replication†Semantic proximity Read ↗

Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cellsSemantic proximity Read ↗

Interferon gene transfer by a hepatitis B virus vector efficiently suppresses wild-type virus infectionSemantic proximity Read ↗

Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis.Semantic proximity Read ↗

Development of Mouse Hepatocyte Lines Permissive for Hepatitis C Virus (HCV)Semantic proximity Read ↗

Mouse APOBEC3 Restricts Friend Leukemia Virus Infection and Pathogenesis In VivoSemantic proximity Read ↗

APOBEC‐mediated interference with hepadnavirus production†Semantic proximity Read ↗

Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3Semantic proximity Read ↗

Susceptibility of different hepatitis B virus isolates to interferon-alpha in a mouse model based on hydrodynamic injection.Semantic proximity Read ↗

Negative Regulation of Interferon-β Gene Expression during Acute and Persistent Virus InfectionsSemantic proximity Read ↗

The lack of HBsAg secretion does neither facilitate induction of antiviral T cell responses nor Hepatitis B Virus clearance in mice.Semantic proximity Read ↗

Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.