Interferon gene transfer by a hepatitis B virus vector efficiently suppresses wild-type virus infection

Abstract excerpt

Hepatitis B viruses specifically target the liver, where they efficiently infect quiescent hepatocytes. Here we show that human and avian hepatitis B viruses can be converted into vectors for liver-directed gene transfer. These vectors allow hepatocyte-specific expression of a green fluorescent protein in vitro and in vivo. Moreover, when used to transduce a type I interferon gene, expression of interferon...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Animal Virus Infections Studies
• Share to Hepatitis B Virus Studies
• Share to Viral gastroenteritis research and epidemiology