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Article

Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells

19 Jul 2013

Abstract excerpt

UNLABELLED: Only humans and chimpanzees are susceptible to chronic infection by hepatitis C virus (HCV). The restricted species tropism of HCV is determined by distinct host factor requirements at different steps of the viral life cycle. In addition, effective innate immune targeting precludes efficient propagation of HCV in nonhuman cells. Species-specificity of HCV host factor usage for cell entry and virus...

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PMID: 23873628
DOI: 10.1002/hep.26626

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