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Article

The lack of HBsAg secretion does neither facilitate induction of antiviral T cell responses nor Hepatitis B Virus clearance in mice.

Antiviral research - 1 Jun 2024

Michler Thomas, Zillinger Jakob, Hagen Philipp, Cheng Fuwang, Festag Julia, Kosinska Anna, Protzer Ulrike

Abstract excerpt

Immune tolerance to the hepatitis B virus (HBV) is crucial for developing chronic hepatitis B, and the HBV surface antigen (HBsAg) produced and secreted in high amounts is regarded as a key contributor. HBsAg is expressed in HBV-infected hepatocytes and those carrying an HBV integration. Whether either HBsAg secretion or the high antigen amount expressed in the liver determines its immunomodulatory properties,...

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Identifiers

PMID: 38679167
DOI: 10.1016/j.antiviral.2024.105896

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