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Article

Negative Regulation of Interferon-β Gene Expression during Acute and Persistent Virus Infections

3 Jun 2011

Abstract excerpt

The production of type I interferons (IFNs) in response to viral infections is critical for antiviral immunity. However, IFN production is transient, and continued expression can lead to inflammatory or autoimmune diseases. Thus, understanding the mechanisms underlying the negative regulation of IFN expression could lead to the development of novel therapeutic approaches to the treatment of these diseases. We...

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PMID: 21677781
DOI: 10.1371/journal.pone.0020681

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